I am frequently frustrated when I come across people who fail to understand the difference between loose and lose so found this article particularly interesting. Its worth reading the whole article but amongst other things it points out:
“A bet you're unlikely to win is a losing proposition. If you're playing Scrabble and your opponent is winning, that means you're losing. You're not loosing. No matter how lopsided the score, you can take comfort from the fact that you're never, ever loosing a game--unless the board is stuck in a tree branch after a tornado and you're knocking it loose.”
Personally I can’t understand how people manage to confuse two words with completely different meanings, it only take a moment to read the sentence and its easy to see the correct word to use in each case. I do, however, take comfort in the fact that there are other people out there who find this just as irritating as I do.